Career Category

Job Description

Amgen is one of the world’s leading independent biotechnology companies. For nearly four decades, Amgen has pioneered biotechnology breakthroughs to bring state-of-the-art medicines from laboratory to the patient. Amgen Research Copenhagen (ARC) is through our DNA Encoded Library (DEL) technology contributing significantly to Amgen’s many small molecule drug discovery projects from hit discovery all the way to drug candidate selection.

We are currently seeking a candidate who will be part of a team bringing projects from hit discovery though lead optimization in collaboration with our colleagues in the US and other sites around the world.

If you are passionate, creative, goal-oriented, openminded, hardworking, and have a desire to do groundbreaking scientific research within a new field of drug discovery, we may have a position for you.

As a member of Discovery Unit I, you will help us drive innovation within targeted protein degradation; one of the fastest growing drug discovery modalities. Amgen has committed significantly to this new exciting field of drug discovery and the DEL technology at ARC is central for this effort. The position will primarily involve chemistry bench work, but also data mining, design of new compounds, and interpretation of biological data. You will be working closely together with other medicinal chemists as well as biologists and participate with your chemistry expertise in the process of identifying, synthesizing, validating, and optimizing hits from our DEL libraries in order to reach project and thereby company goals.

Specifically, tasks will include:

·       Synthesis and characterization of screening hits and related compounds

·       Development of synthesis strategies & Guidance of CRO chemists

·       Design and execution of hit follow-up campaigns incl. SAR explorations

·       Analysis of DEL selection data

·       Interpretation of biological data

·       Presentation of scientific results at team meetings

·       Teamwork in a fast-moving and international environment

We offer a highly rewarding and stimulating environment in a world-class drug discovery organisation. The position is based in our office in Copenhagen.

The employee will report to Scientific Director and leader of Discovery Unit I, Sanne Glad. For further information contact: HR Manager Helena Pechter (hpechter@amgen.com)

Qualifications:

Candidates should hold a Ph.D. in organic chemistry or related disciplines with a solid understanding of organic and medicinal chemistry. The ideal candidate will have:

·       Strong theoretical and hands-on experience within organic synthesis

·       Knowledge of medicinal chemistry and drug discovery

·       Knowledge of targeted protein degradation is an advantage

·       Interest in handling and analyzing large data sets

·       Excellent collaborations and team player skills

·       Excellent English communication skills

·       Outspoken personality with an urge for creating high-quality results

Application:

Please note that it is required to have permit to live and work in Denmark for application. All applications and contacts are confidential. We want your application as soon as possible, since selection starts instantly.