Computational Structural Biologist
上海药明生物技术有限公司ShanghaiUpdate time: August 28,2019
Job Description
KEY ACCOUNTIBILITIES:
- Perform bioinformatics analysis to support project progression.
- Provide scientific support to project patent application.
- Provide structural level interpretations on experimental data, and conduct rational design to engineer protein developability (e.g. aggregation, thermostability, etc.).
- Conduct protein data-mining and extract statistics from public databases (e.g. PDB, NCBI database, etc.)
- Maintain and further develop an internal protein bioinformatics platform.
- Maintain and further develop an internal high performance computing cluster and two bioinformatics web sites.
- Work with IT specialists to automate routine data process and workload management.
REQUIREMENTS:
PhD (or equivalent experience) in structural bioinformatics, structural biology, computational biology, computational chemistry, etc.- Familiarity with protein sequences, structures and associated physical & chemical properties.
- Familiarity with protein modeling and in silico design, protein engineering;
- Experience in antibody design will be advantageous.
- Hands-on experience on molecular modelling tools (e.g. Discovery Studio, Rosetta, Schrodinger Bioluminate, PyMOL, Gromacs, etc.);
- Proficient in Linux working environment.
- Experience in web development. Familiarity with HTML, CSS, PHP, JavaScript, MySQL etc.
- Familiarity with public bioinformatics tools (e.g. BLAST, CD-HIT, HMMER etc.).
- Excellent programming skills. Expertise in Bash scripting and Python scripting; Experience in BioPython library will be a plus.
- Wet-lab experience will be a plus.
- Industry experience preferred.
- NGS data mining experience will be an advantage.
- Excellent written and verbal skills in both English and Mandarim.
职能类别: 生物工程/生物制药 高级软件工程师
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联系方式
上班地址:上海市外高桥保税区富特中路288号
部门信息
所属部门:生物新药研发服务部
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